Structural insights into the evolution of the pantothenate-biosynthesis pathway.
نویسندگان
چکیده
Pantothenate is synthesized in bacteria, fungi and plants, and as vitamin B5 is a dietary requirement in animals. The three-dimensional structures of the four Escherichia coli enzymes involved in the production of pantothenate have been determined. We describe the use of comparative analyses of the sequences and structures to identify distant homologues of the four enzymes in an attempt to understand the evolution of the pathway. We conclude that it is likely to have evolved via a patchwork mechanism, whereby the individual enzymes were recruited separately.
منابع مشابه
Coenzyme A biosynthesis: reconstruction of the pathway in archaea and an evolutionary scenario based on comparative genomics.
Coenzyme A (CoA) holds a central position in cellular metabolism and therefore can be assumed to be an ancient molecule. Starting from the known E. coli and human enzymes required for the biosynthesis of CoA, phylogenetic profiles and chromosomal proximity methods enabled an almost complete reconstruction of archaeal CoA biosynthesis. This includes the identification of strong candidates for ar...
متن کاملThe Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A
Coenzyme A (CoA) is an ubiquitous and essential cofactor, synthesized from the precursor pantothenate. Vitamin biosynthetic pathways are normally tightly regulated, including the pathway from pantothenate to CoA. However, no regulation of pantothenate biosynthesis has been identified. We have recently described an additional component in the pantothenate biosynthetic pathway, PanZ, which promot...
متن کاملTranscriptional Response of Structural and Regulatory Genes Involved in Isoprene Biosynthesis and its Relation to Essential Oil Biosynthesis in Response to Salicylic Acid and Abscisic Acid in Mentha piperita L.
Background: In peppermint, precursors for the biosynthesis of monoterpenes are provided by plastidial methyl-erythritol-phosphate (MEP) pathways. Objective: In order to increase our understanding of terpene metabolism in M. piperita, the effect of salicylic acid (SA) and abscisic acid (ABA) in the modulation of expression pattern of genes involved in essential oil biosynthesis and secretion wa...
متن کاملGenetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito
Coenzyme A (CoA) is an essential universal cofactor for all prokaryotic and eukaryotic cells. In nearly all non-photosynthetic cells, CoA biosynthesis depends on the uptake and phosphorylation of vitamin B5 (pantothenic acid or pantothenate). Recently, putative pantothenate transporter (PAT) and pantothenate kinases (PanKs) were functionally characterized in P. yoelii. PAT and PanKs were shown ...
متن کاملStructural dynamics in northern Atlas of Tunisian, Jendouba area: insights from geology and gravity data
This paper presents a new interpretation of the geometry of Triassic alignment of J. Sidi Mahdi –J. Zitoun in Medjerda Valley Plain (Northern Tunisia) based on detailed analysis of gravity and seismic reflection data. The main results of gravity analysis do not show a distinguish gravity anomaly over Triassic evaporites bodies. The positive gravity anomaly seems to be related to the entire stru...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 31 Pt 3 شماره
صفحات -
تاریخ انتشار 2003